AACR 2017: The Path forward
Immune Checkpoints and Immunosurveillance, Molecular Targeted Therapies, Biomarker Discovery, Drug Resistance and Growth Signalling Pathways: PamGene and our collaborators presented key advancements in these areas with 5 posters at the Annual Meeting of the American Association of Cancer Research in Washington DC (April 1st to 5th, 2017).


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See Abstract links and Download Posters here
Predictive Biomarkers (Session PO.CL10.04)
Immune system pathway activation for prediction of the response to neoadjuvant chemotherapy in triple-negative breast cancer 
Abstract Link

April 3, 2017, 8:00 - 12:00 PM  Section 32 ​Poster 1792 / 22
Presenter/Authors
Takeshi Sawada1, Riet Hilhorst2, Savithri Rangarajan2, Masayuki Yoshida3, Kenji Tamura3, Rinie van Beuningen2, Rob Ruijtenbeek2, Hitoshi Tsuda4, Fumiaki Koizumi1
1 Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan; 2 PamGene International BV, 's-Hertogenbosch, Netherlands; 3 National Cancer Center Hospital, Tokyo, Japan; 4 National Defense Medical College, Saitama, Japan

Molecular Targeted Therapies (Session PO.ET04.01)
Discovery of a kinome signature predicting sensitivity and resistance to RAF-MAPK pathway inhibitors in melanoma 
Abstract Link

April 4, 2017, 8:00 - 12:00 PM  Section 6 Poster 3163 / 23 
Presenter/Authors
Riet Hilhorst1, Mohammed Krayem2, Adrienne van den Berg1, Fabrice Journe2, Liesbeth Hovestad-Bijl1, Tim van den Hooven1, Rik de Wijn1, Philippe Aftimos2, Ghanem Ghanem2, Rob Ruijtenbeek1
1 PamGene International BV, 's-Hertogenbosch, Netherlands; 2 Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium


Immune Checkpoints and Immunosurveillance (Session PO.IM02.12) 
Correlation of phosphatase activity with lymphocyte infiltrates in metastatic renal cell carcinoma tissues 
Abstract Link
April 5, 2017, 8:00 - 12:00 PM  Section 25 Poster 5608 / 10 
Presenter/Authors

Rob Ruijtenbeek1, Liesbeth Houkes-van Kerkhoff1, Jeannette Oosterwijk2, Liesbeth Hovestad-Bijl1, Riet Hilhorst1, Alejandro H. Gomez3, Juan F. Rodriguez3, Jesus Garcia-Donas3, Bart Kiemeney2, Egbert Oosterwijk2
1 PamGene International B.V., BJ's-Hertogenbosch, Netherlands; 2 Radboud University Medical Center, Nijmegen, Netherlands; 3 Centro integral oncológico Clara Campal, Madrid, Spain


Reversal of Drug Resistance (Session PO.ET04.05)
Comprehensive high-throughput screen for combination therapies to block acquired resistance to targeted drugs
Abstract Link
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April 3, 2017, 8:00 - 12:00 PM Section 6 Poster 1190/5
Presenter/Authors
Izhak Haviv
Bar Ilan Univ., Zfat, Israel






Cell Growth Signaling Pathways 5 (Session PO.MCB01.05)
A kinome analysis of the molecular pharmacodynamics of PT-112 in a human cancer cell line
Abstract Link
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April 3, 2017, 1:00 - 5:00 PM Section 15 Poster 2378 / 20
Presenter/Authors
Diego Tosi1, Esther Perez-Gracia1, Philippe Pourquier1, Tyler D. Ames2, Richard A. Wing2, José Jimeno2, Céline Gongora1
1Institut de Recherche en Cancérologie de Montpellier, Montpellier, France; 2Phosplatin Therapeutics, New York, NY