Insights into nuclear receptor functions in 4 publications this year
Interesting publications in 2015, from research groups that have used PamGene's Nuclear receptor profiling technology, highlight novel applications that provide insights into nuclear receptor function.
Here we have provided links to these publications.
 
Destabilization of the torsioned conformation of a ligand side chain inverts the LXRβ activity.
Álvarez LD, Virginia Dansey M, Grinman DY, Navalesi D, Samaja GA, Celeste Del Fueyo M, Bastiaensen N, Houtman R, Estrin DA, Veleiro AS, Pecci A, Burton G. Biochim Biophys Acta. (2015) Oct 3. pii: S1388-1981(15)00180-8. doi: 10.1016/j.bbalip.2015.09.007. [Epub ahead of print]
 
The effect of glucuronidation on isoflavone induced estrogen receptor (ER)α and ERβ mediated coregulator interactions.
Beekmann K, de Haan LH, Actis-Goretta L, Houtman R, van Bladeren PJ, Rietjens IM. J Steroid Biochem Mol Biol. (2015) Sep 7. pii: S0960-0760(15)30066-2. doi: 10.1016/j.jsbmb.2015.09.002. [Epub ahead of print]
 
A mixed glucocorticoid/mineralocorticoid selective modulator with dominant antagonism in the male rat brain.
Atucha E, Zalachoras I, van den Heuvel JK, van Weert LT, Melchers D, Mol IM, Belanoff JK, Houtman R, Hunt H, Roozendaal B, Meijer OC. Endocrinology. (2015) Aug 25:en20151390. [Epub ahead of print]
 
Subtype-specific modulation of estrogen receptor-coactivator interaction by phosphorylation.
Tharun IM, Nieto L, Haase C, Scheepstra M, Balk M, Möcklinghoff S, Adriaens W, Dames SA, Brunsveld L. ACS Chem Biol. (2015) Feb 20;10(2):475-84
 

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