Applications in Disease areas

Applications of PamChip® kinase activity profiling in different disease areas are illustrated.

Disease Area Publication Links

Alzheimer’s Disease (AD)

Rosenberger AF et al (2015) J Alzheimers Dis. Oct 27. [Epub ahead of print]
Hoozemans JJM et al (2014) J Clin Cell Immunol 5: 243
Rosenberger AF et al (2014 I4H Poster)
Hoozemans JJM et al (2012) Neurodegener. Dis. 10 (1-4): 46-8
Rosenberger AF et al (2011 CHAINS Poster)
 
Brain tumors
 
Sikkema AH et al (2009)  Cancer Res. 69 (14): 5987-95 
 
Breast Cancer 
 
Sawada T et al (2017 AACR Poster 1792)
Houtman R et al (2014 
Keystone Symposia Poster)
Lindholm EM et al (2012) Mol Oncol. 6 (4): 418-27
Hilhorst R et al (2009 AACR Poster)
 
Colon cancer
 
van den Oord R et al (2013 AACR Poster 5586)
Colorectal cancer (CRC)
 
Chocry M (2017) 10;8(61):103710-103730
Risberg K et al (2016) BMC Cancer. Jul 26;16:531.
Hilhorst R et al (2014 
AACR Poster 5511)
 
Diabetes See Metabolic disorders
 
Duchenne muscular dystrophy (DMD) 
 
Zeng F et al (2008) Hum. Mutat. 29 (1):190-7
Gastric cancer
 
Koh Y et al (2013 AACR Poster 4655)
Koh Y et al (2011
AACR Poster 4468)
 
Gastroesophageal adenocarcinoma (GEC)
 
Catenacci D et al (2014 AACR Poster 2725)
Glioblastoma
 
Gilbert AN et al (2016) J Vis Exp. (112). doi: 10.3791/54026
Anderson JC et al (2014) Radiother Oncol. 111 (3): 468-74
 
Glioma
 
Stoltz K et al (2014) Neuro Oncol. Epub. pii: nou320
 
HIV
 
Duverger A et al (2014) J Virol. 88(1):364-76
Idiopathic mental retardation
 
Rooms L et al (2011) Am J. Med Genet A. 155A(2):343-8
Infantile hemangioma 
 
Jinnin M et al (2008) Nat Med. 14 (11): 1236-46
 
Ischaemic stroke, myocardial infarction 
 
Tournoij E et al (2012) Platelets. 23 (8): 617-25
 
Kidney cancer See Renal Cancer below
 
Leukemia 
(incl. AML, CLL)
 
Ter Elst A et al (2011) Leuk Lymphoma. 52 (1): 122-30
Eriksson A et al (2014) Biochem Pharmacol. 87 (2): 284-91
 
Liver cancer
 
Yokohira M et al (2006) J Toxicol Pathol Vol. 19 37-45.
 
Lung cancer (NSCLC) and other solid tumors 
 
Arni S et al (2018) Analytical Biocemistry 547:77-83
Arni S et al (2017) Oncotarget Aug 2;8(40):68599-68613
Steen NV et al (2017) Am J Cancer Res. 7(4):816-830
Galvani E et al (2015) Oncotarget. 15; 6(40): 42717-32
Ferguson BD et al (2015)  Sci Rep. 5:10641
Anderson JC et al (2014) PLoS One. 9 (12): e116388;
Kawada I et al (2014) Cancer Res. 74 (3): 884-95
Izawa N et al (2014 AACR Poster 4248)
Arni S et al (2013
AACR Poster 2366)
Ruijtenbeek R et al (2011
AACR Poster 4113)
Hilhorst R et al (2011
ASCO Poster)
Hilhorst R et al (2010
ASCO poster)
Vivanco I et al (2010) Proc Natl Acad Sci USA. 107 (14): 6459-64
Versele M et al (2009) Mol Cancer Ther. 8 (7): 1846-55
Hilhorst et al (2009 WCLC Poster)
 
Malignant peripheral nerve sheath tumors (MPNSTs)
 
Brosius SN (2014) 73(11):1078-90
Melanoma
 
Hilhorst R et al (2017 AACR Poster 3163)
Tahiri A et al (2013) PLoS ONE 8 (8): e72692
Tahiri A et al (2012 AACR Poster 863)
 
Meningioma (Atypical) Anderson JC et al (2015)  Med Res Arch. 2015 (3). doi: 10.18103/mra.v0i3.104
 
Metabolic disorders
Rabhi N et al (2017) Mol Metab. S2212-8778(17)30935-3
Lagarrigue S, Lopez-Mejia IC et al (2015) J Clin Invest. 2015. doi:10.1172/JCI81480
 
Multiple endocrine neoplasia Type 2 (MEN2) Plaza-Menacho I et al (2011)  Biol Chem. 13;286(19):17292-302.
See also Thyroid cancer
 
Multiple sclerosis (MS)
Qin J et al (2018) J. Neurosci. 11;37 (41):9925-9938
 
Myeloproliferative neoplasms 
 
Bar-Natan M et al (2012) Leukemia. 26 (6): 1407-10
Sanz A et al (2011) PLoS One. 6 (4): e18522
 
Neuroblastoma Hilhorst R et al (2012 AACR Poster 1683)
 
Neuroendocrine tumors (NETs)
 
Romano D et al (2018 ENETS Poster)
Romano D et al (2017 ENETS Poster and Abstract)
Oropharyngeal squamous cell carcinomas (OPSCC)
 
Isayeva T et al (2014) Mod Pathol. 28 (5): 631-53
 
Osteosarcoma
 
Kuijjer ML et al (2014) BMC Med Genomics. 7:4
 
Pancreatic cancer Rangarajan S et al (2011 TAT Poster)
Rangarajan S et al (2010
ENA Poster)
 
Penile squamous cell carcinoma (PSCC)
 
Yang ES et al (2017) Oncotarget 8(13):21710-21718
Prostate cancer 
 
Bratland A et al (2009) Clin Exp Metastasis. 26 (5): 485-96
Røe K et al  (2013) PLoS ONE 8(5): e63723
 
Rectal cancer (Locally advanced rectal cancer)
 
Ree AH et al (2015) Crit Rev Oncol Hematol. pii: S1040-8428(15)00004-9
Ree AH et al (2012) PLoS One. 7 (11): e50806
Saelen MG et al (2011) Angiogenesis. 14(4):481-9
Ree AH et al (2011 MTCT Poster
Folkvord S et al (2010) Int J Radiat Oncol Biol Phys. 78 (2): 555-62
 
Renal Cell Carcinoma
Ghosh AP et al (2017) Oncotarget. Apr 25;8(17):29220-29232
van der Zanden LF et al (2017) Urol Oncol. Apr 3. pii: S1078-1439(17)30109-6
Ruijtenbeek R et al (2017 AACR Poster 5608)
Noé G et al (2016) Oncotarget. Aug 29. doi: 10.18632/oncotarget.11686.
Bellesoeur A et al (2016 AACR Poster 2038)
Anderson JC et al (2015) PLoS One. 2015 Sep 25;10(9):e0139267
Ruijtenbeek R et al (2015 AACR Poster 2677)
Ruijtenbeek R et al (2009 
AACR Poster)
 
Rheumatoid Arthritis (RA)
 
Wesseling JG et al (2011 CTMM Poster)
Schizophrenia
 
McGuire JL et al (2014). Brain Res. 1568: 42-54
 
Synovial Sarcoma
Qiao Z et al (2018)  Oncotarget. 8(65):109587-109595
Oyama R et al (2017) Sci Rep. 7(1):4712.
 
Thyroid Cancer Hilhorst MH et al (2015 AACR Poster 4322)
See also Multiple endocrine neoplasia 
 
Uveal melanoma 
 
Maat W et al (2009) Br J Cancer. 101 (2): 312-9