Relevance of Nuclear Receptors
Nuclear receptors regulate gene expression levels by gene promotor binding and by recruitment of coregulators. Cofactor recruitment is a crucial regulatory step in nuclear receptor (NR) signal transduction. The pathways towards gene expression involve ligand-dependent and independent interactions between NR and coregulator (CoR) proteins. In view of drug development, profiling these NR-CoR interactions is of importance to understand mechanisms of drug action, to steer drug specificity, to understand putative adverse drug effects (on- versus off target), and to tailor the pharmacotherapies.