Relevance of Kinases
Kinases are the most intensively studied protein targets in pharmacology research, as seen from the increasing number of kinase-targeting inhibitors in clinical trials. However, of the potential 518 kinase targets, less than 15 % are described in preclinical and clinical development, and less than 5% appear on the current FDA-approved list, lending target discovery a renewed focus. 
 
Download our white paper describing research on kinases and their inhibitors:

 
PamGene's unique position to understand kinases
 
 
Traditional approaches frequently study the abundance of proteins rather than their activity, and therefore functional proteomics assays bring on a new dimension and additional information about how cell signalling works. 

PamGene's activity-based kinase assay detects kinases directly on a functional level, and this allows testing the drug (kinase inhibitor) directly on patient material (clinical biopsy). The rationale is that in case the kinase target present in the patient sample is not responsive to a proposed drug, this is expected to reduce the possibility of treatment success, allowing the investigation of response biomarkers.This leads to innumerable applications in basic and translational research.

What is the role of protein kinases in signal transduction and cancer? We have briefly summarized background information, that you can find here:

To find out more about how our functional assays can help in your basic molecular and cell biology as well as preclinical, clinical and translational research, please browse our Services Section and contact us directly!