Below is a selection of scientific publications from a variety of applications possible with PamGene's technology. For further information or reprints, please email us at info@pamgene.com

Prediction of Response to Preoperative Chemoradiotherapy in Rectal Cancer by Multiplex Kinase Activity Profiling.
Sigurd Folkvord, Kjersti Flatmark, Svein Dueland, Rik de Wijn, Krystyna Kotanska Grøholt, Jahn M. Nesland, Knut H. Hole, Piet J. Boender, Rob Ruijtenbeek, Marianne Johansen, Karl-Erik Giercksky, and Anne Hansen Ree.
Int J Radiat Oncol Biol Phys. 2010 Jul 31
www.ncbi.nlm.nih.gov/pubmed/20675069

 

Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray.

Parera Pera N, Branderhorst HM, Kooij R, Maierhofer C, van der Kaaden M, Liskamp RM, Wittmann V, Ruijtenbeek R, Pieters RJ.

Chembiochem. 2010 Jul 29

www.ncbi.nlm.nih.gov/pubmed/20672284

 

Triple-negative breast cancer: Present challenges and new perspectives.

Podo F, Buydens LM, Degani H, Hilhorst R, Klipp E, Gribbestad IS, Van Huffel S, W M van Laarhoven H, Luts J, Monleon D, Postma GJ, Schneiderhan-Marra N, Santoro F, Wouters H, Russnes HG, Sørlie T, Tagliabue E, Børresen-Dale AL.

Mol Oncol. 2010 Apr 24

www.ncbi.nlm.nih.gov/pubmed/20537966

 

The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.

Vivanco I, Rohle D, Versele M, Iwanami A, Kuga D, Oldrini B, Tanaka K, Dang J, Kubek S, Palaskas N, Hsueh T, Evans M, Mulholland D, Wolle D, Rajasekaran S, Rajasekaran A, Liau LM, Cloughesy TF, Dikic I, Brennan C, Wu H, Mischel PS, Perera T, Mellinghoff IK.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6459-64. Epub 2010 Mar 22

www.ncbi.nlm.nih.gov/pubmed/20308550

 

Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors.

van Ameijde J, Poot AJ, van Wandelen LT, Wammes AE, Ruijtenbeek R, Rijkers DT,

Liskamp RM.

Org Biomol Chem. 2010 Apr 7;8(7):1629-39. Epub 2010 Feb 4.

www.ncbi.nlm.nih.gov/pubmed/20237675

 

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

Koppen A, Houtman R, Pijnenburg D, Jeninga EH, Ruijtenbeek R, Kalkhoven E.

Mol Cell Proteomics. 2009 Oct;8(10):2212-26.

www.ncbi.nlm.nih.gov/pubmed/19596656

 

Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays.

Poot AJ, van Ameijde J, Slijper M, van den Berg A, Hilhorst R, Ruijtenbeek R, Rijkers DT, Liskamp RM.

Chembiochem. 2009 Aug 17;10(12):2042-51.

www.ncbi.nlm.nih.gov/pubmed/19618415

 

Bioactivity-guided mapping and navigation of chemical space.

Renner S, van Otterlo WA, Dominguez Seoane M, Möcklinghoff S, Hofmann B, Wetzel S, Schuffenhauer A, Ertl P, Oprea TI, Steinhilber D, Brunsveld L, Rauh D, Waldmann H.

Nat Chem Biol. 2009 Aug;5(8):585-92.

www.ncbi.nlm.nih.gov/pubmed/19561619

 

Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling.

Bratland A, Boender PJ, Høifødt HK, Østensen IH, Ruijtenbeek R, Wang MY, Berg JP, Lilleby W, Fodstad Ø, Ree AH.

Clin Exp Metastasis. 2009;26(5):485-96.

www.ncbi.nlm.nih.gov/pubmed/19294521

 

Episodic Src activation in uveal melanoma revealed by kinase activity profiling.

Maat W, el Filali M, Dirks-Mulder A, Luyten GP, Gruis NA, Desjardins L, Boender P, Jager MJ, van der Velden PA.

Br J Cancer. 2009 Jul 21;101(2):312-9.

www.ncbi.nlm.nih.gov/pubmed/19568237

 

Kinome profiling in pediatric brain tumors as a new approach for target discovery.

Sikkema AH, Diks SH, den Dunnen WF, ter Elst A, Scherpen FJ, Hoving EW, Ruijtenbeek R, Boender PJ, de Wijn R, Kamps WA, Peppelenbosch MP,

de Bont ES.

Cancer Res. 2009 Jul 15;69(14):5987-95.

www.ncbi.nlm.nih.gov/pubmed/19567681

 

Response prediction to a multitargeted kinase inhibitor in cancer cell lines and xenograft tumors using high-content tyrosine peptide arrays with a kinetic readout.

Versele M, Talloen W, Rockx C, Geerts T, Janssen B, Lavrijssen T, King P, Göhlmann HW, Page M, Perera T.

Mol Cancer Ther. 2009 Jul;8(7):1846-55.

www.ncbi.nlm.nih.gov/pubmed/19584230

 

Peptide microarrays for detailed, high-throughput substrate identification, kinetic characterization, and inhibition studies on protein kinase A.

Hilhorst R, Houkes L, van den Berg A, Ruijtenbeek R.

Anal Biochem. 2009 Apr 15;387(2):150-61.

www.ncbi.nlm.nih.gov/pubmed/19344656

 

Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases.

De Keersmaecker K, Versele M, Cools J, Superti-Furga G, Hantschel O.

Leukemia. 2008 Dec;22(12):2208-16.

www.ncbi.nlm.nih.gov/pubmed/18784740

 

Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.

Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR.

Nat Med. 2008 Nov;14(11):1236-46.

www.ncbi.nlm.nih.gov/pubmed/18931684

 

Multivalent carbohydrate recognition on a glycodendrimer-functionalized flow-through chip.

Branderhorst HM, Ruijtenbeek R, Liskamp RM, Pieters RJ.

Chembiochem. 2008 Jul 21;9(11):1836-44.

www.ncbi.nlm.nih.gov/pubmed/18604837

 

Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.

Sanderson LM, de Groot PJ, Hooiveld GJ, Koppen A, Kalkhoven E, Müller M, Kersten S.

PLoS One. 2008 Feb 27;3(2).

www.ncbi.nlm.nih.gov/pubmed/18301758

 

Array-MLPA: comprehensive detection of deletions and duplications and its application to DMD patients.

Zeng F, Ren ZR, Huang SZ, Kalf M, Mommersteeg M, Smit M, White S, Jin CL, Xu M, Zhou DW, Yan JB, Chen MJ, van Beuningen R, Huang SZ, den Dunnen J, Zeng YT, Wu Y.

Hum Mutat. 2008 Jan;29(1):190-7

www.ncbi.nlm.nih.gov/pubmed/17854090

 

Protein-tyrosine kinase activity profiling in knock down zebrafish embryos.

Lemeer S, Jopling C, Naji F, Ruijtenbeek R, Slijper M, Heck AJ, den Hertog J.

PLoS One. 2007 Jul 4;2(7):e581.
www.ncbi.nlm.nih.gov/pubmed/17611617

 

Endogenous phosphotyrosine signaling in zebrafish embryos.

Lemeer S, Ruijtenbeek R, Pinkse MW, Jopling C, Heck AJ, den Hertog J, Slijper M.

Mol Cell Proteomics. 2007 Dec;6(12):2088-99.

www.ncbi.nlm.nih.gov/pubmed/17698882

 

Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach.

Heneweer M, Houtman R, Poortman J, Groot M, Maliepaard C, Peijnenburg A.

Toxicol Sci. 2007 Sep;99(1):303-14.

www.ncbi.nlm.nih.gov/pubmed/17557909

 

Microarray MAPH: accurate array-based detection of relative copy number in genomic DNA.

Gibbons B, Datta P, Wu Y, Chan A, Al Armour J.

BMC Genomics. 2006 Jun 30;7:163.

www.ncbi.nlm.nih.gov/pubmed/16813644

 

Use of hybridization melting kinetics for detecting Phytophthora species using three-dimensional microarrays: demonstration of a novel concept for the differentiation of detection targets.

Anderson N, Szemes M, O'Brien P, de Weerdt M, Schoen C, Boender P, Bonants P.

Mycol Res. 2006 Jun;110(Pt 6):664-71. Epub 2006 Jun 12.

www.ncbi.nlm.nih.gov/pubmed/16769210

 

Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences.

Kuribayashi M, Asamoto M, Suzuki S, Hokaiwado N, Ogawa K, Shirai T.

Cancer Lett. 2006 Feb 8;232(2):289-99. Epub 2005 Apr 22

www.ncbi.nlm.nih.gov/pubmed/16458123

 

Use of a three-dimensional microarray system for detection of levofloxacin resistance and the mec A gene in Staphylococcus aureus.

Nagaoka T, Horii T, Satoh T, Ito T, Monji A, Takeshita A, Maekawa M.

J Clin Microbiol. 2005 Oct;43(10):5187-94.

www.ncbi.nlm.nih.gov/pubmed/16207982

 

Direct detection of Staphylococcus aureus mRNA using a flow through microarray. Anthony RM, Schuitema AR, Oskam L, Klatser PR.

J Microbiol Methods. 2005 Jan;60(1):47-54.

www.ncbi.nlm.nih.gov/pubmed/15567224

 

Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system.

Hokaiwado N, Asamoto M, Tsujimura K, Hirota T, Ichihara T, Satoh T, Shirai T.

Cancer Sci. 2004 Feb;95(2):123-30.

www.ncbi.nlm.nih.gov/pubmed/14965361

 

Quantitative assessment of a novel flow-through porous microarray for the rapid analysis of gene expression profiles.

Wu Y, de Kievit P, Vahlkamp L, Pijnenburg D, Smit M, Dankers M, Melchers D, Stax M, Boender PJ, Ingham C, Bastiaensen N, de Wijn R, van Alewijk D, van Damme H, Raap AK, Chan AB, van Beuningen R.

Nucleic Acids Res. 2004 Aug 27;32(15).

www.ncbi.nlm.nih.gov/pubmed/15333674

 

Effect of secondary structure on single nucleotide polymorphism detection with a porous microarray matrix; implications for probe selection.

Anthony RM, Schuitema AR, Chan AB, Boender PJ, Klatser PR, Oskam L.

Biotechniques. 2003 May;34(5):1082-6, 1088-9.

www.ncbi.nlm.nih.gov/pubmed/12765035

 

Multiplex detection of plant (quarantine) pathogens by micro-arrays. An innovative tool for plant health management Acta.

Schoen, C.D., de Weerdt, M., Szemes, M., Bonants, P., van Beuningen, R., Chan, A., Hilhorst, R. and Boender, P.

Hort. (ISHS) 657:553-558

www.actahort.org/books/657/657_90.htm

 

Beta-Globin mutation detection by tagged single-base extension and hybridization to universal glass and flow-through microarrays.

van Moorsel CH, van Wijngaarden EE, Fokkema IF, den Dunnen JT, Roos D, van Zwieten R, Giordano PC, Harteveld CL.

Eur J Hum Genet. 2004 Jul;12(7):567-73.

www.ncbi.nlm.nih.gov/pubmed/15069457

 

Three-dimensional microarray compared with PCR-single-strand conformation polymorphism analysis/DNA sequencing for mutation analysis of K-ras codons 12 and 13.

Maekawa M, Nagaoka T, Taniguchi T, Higashi H, Sugimura H, Sugano K, Yonekawa H, Satoh T, Horii T, Shirai N, Takeshita A, Kanno T.

Clin Chem. 2004 Aug;50(8):1322-7. Epub 2004 Jun 3.

www.ncbi.nlm.nih.gov/pubmed/15178652

 

Basic studies on mutation analysis of K-ras codon 12 by use of three-dimensional microarray system.

Maekawa M, Taniguchi T, Tatebayashi C, Horii T, Takeshita A, Sugimura H, Sugano K, Yonekawa H, Nagaoka T, Kanno T.

Rinsho Byori. 2003 Apr;51(4):306-12.

www.ncbi.nlm.nih.gov/pubmed/12747251

 

A COX-2 Inhibitor SC58125, Promotes Liver Carcinogenesis in a Rat Medium-Term Liver Bioassay, Possibly due to Induction of CYP 2B1 and 3A1.

Masanao Yokohira, Hijiri Takeuchi, Keiko Yamakawa, Kousuke Saoo, Yoko Matsuda, Yu Zeng, Kyoko Hosokawa, Hajime Maeta and Katsumi Imaida. (2006), J Toxicol Pathol Vol. 19; 37-45.

www.jstage.jst.go.jp/article/tox/19/1/19_37/_article

 

Fast and specific hybridization using flow-through microarrays on porous metal oxide.

van Beuningen, R., van Damme, H., Boender, P., Bastiaensen, N., Chan, A, and Kievits, T.

Clin. Chem. 47, 1931 –1933

www.clinchem.org/cgi/content/extract/47/10/1931